Mission: Impossible II (marketed as M:I-2 and on Blu-ray as Mission: Impossible 2) is a 2000 American action spy film directed by John Woo and starring Tom Cruise, who also served as the film's producer. It is the sequel to Brian De Palma's 1996 film Mission: Impossible and has Cruise reprising his role as Agent Ethan Hunt of the IMF, a top-secret espionage and clandestine operation agency. The film is the second installment of the Mission: Impossible film series and was followed by Mission: Impossible III (2006), Mission: Impossible – Ghost Protocol (2011), and Mission: Impossible – Rogue Nation (2015).
Ethan Hunt, while on holiday, is alerted by the IMF that someone has used his identity to assist Russian molecular biologist, Dr. Vladimir Nekhorvich, of Biocyte Pharmaceuticals to enter the United States, only to kill him in a subsequent plane crash. Nekhorvich, an old friend of Ethan, had forewarned the IMF of his arrival, planning to deliver a new bio-weapon, Chimera, and its cure, Bellerophon, both of which he was forced to develop by Biocyte, into the IMF's hands. With his death, IMF is worried that the virus is out in the open, believing that rogue IMF agent Sean Ambrose is responsible. IMF assigns Ethan to recover it. Ethan is told that he can select two members of his team to help him, but the third person to help him must be Nyah Nordoff-Hall, a professional thief presently operating in Seville, Spain, as she will be able to get close to Ambrose, being an ex-girlfriend.
After recruiting Nyah, Ethan meets two members of his team--computer expert Luther Stickell and pilot Billy Baird in Sydney, Australia, where Biocyte laboratories are located along with Ambrose's residence. As Ethan and the others stake out Biocyte, Nyah gets close to Ambrose and begins to work him for information related to the Chimera virus. Later at Ambrose's house, Hugh doubts Nyah's loyalty to Ambrose and Ambrose rewards him by snapping off a portion of his left finger. At a horse racing event, Ambrose quietly meets with Biocyte's CEO, John C. McCloy, and shows him a video of the Chimera virus affecting one of Nekhorvich's colleagues, taken from Biocyte, so he can blackmail McCloy into cooperating with them. Nyah is able to pocket the video footage long enough to transfer it to Ethan and his team, who learn that the Chimera virus has a 20-hour dormant period before it causes death through mass destruction of the victim's red blood cells. Bellerophon can save the victim only if used within that 20-hour window.
The IMF team kidnaps McCloy and learns that Nekhorvich had actually injected himself with Chimera, the only way he could smuggle the virus from Biocyte, and had all the known samples of Bellerophon, now presently in Ambrose's hands. Ambrose had forced McCloy to sell him the virus for £37,000,000 in exchange for the samples of Bellerophon. Ethan's team plans to break into Biocyte and destroy the virus. Ambrose, posing as Ethan, tricks Nyah into revealing Ethan's plan. Ambrose secures Nyah and prepares to raid Biocyte himself to secure the virus. Ethan is able to destroy all but one sample of the virus before Ambrose interrupts him, and a firefight ensues. Ethan learns that Ambrose is holding Nyah and stops firing, during which Ambrose orders Nyah to retrieve the last sample. When she does so, she injects herself with it, thus preventing Ambrose from simply killing her to get it. As Ambrose takes Nyah and Ethan escapes from the laboratory in the ensuing gun battle between Ambrose's men and Biocyte security personnel, Ethan starts a 20-hour countdown before the virus takes over Nyah's body.
Ambrose opts to let Nyah wander the streets of Sydney in a daze, intending to trigger a Chimera pandemic in Australia, and orders McCloy to effectively hand over enough control of Biocyte to make him the majority shareholder; Ambrose's plan is now to make a fortune when prices of Biocyte's stock skyrocket due to demand for Bellerophon. Ethan's team is able to locate and infiltrate the meeting, stealing the samples of Bellerophon while taking out many of Ambrose's men. Luther and Billy locate Nyah, who has wandered to a cliff side, intent on killing herself to prevent Chimera from spreading. As the two IMF agents bring Nyah to Ethan, he and Ambrose engage in a fistfight. With little time left on the 20-hour countdown, Ethan finally gains the upper hand over Ambrose and kills him, and Luther injects Nyah with Bellerophon. IMF clears Nyah's criminal record, and allows Ethan to continue his vacation with her in Sydney.
- Tom Cruise as Ethan Hunt
- Ving Rhames as Luther Stickell
- Dougray Scott as Sean Ambrose
- Thandie Newton as Nyah Nordoff-Hall
- Richard Roxburgh as Hugh Stamp
- John Polson as Billy Baird
- Brendan Gleeson as John C. McCloy
- William Mapother as Wallis
- Mathew Wilkinson as Michael
- Rade Serbedzija as Dr. Nekhorvich
- Anthony Hopkins as Swanbeck (uncredited)
- Dominic Purcell as Ulrich
- Christian Manon as Dr. Gradsky
- Unknown actor as Simon